- Original Article
- Apoptotic Pathway Induced by Dominant Negative ATM Gene in CT-26 Colon Cancer Cells
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Jung Chang Lee, Ho Keun Yi, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang, Jin Woo Park
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Clin Exp Pediatr. 2003;46(7):679-686. Published online July 15, 2003
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Purpose : Ataxia telangiectasia mutated(ATM) is involved in DNA damage responses at different cell cycle checkpoints, and signalling pathways associated with regulation of apoptosis in response to ionizing radiation(IR). However, the signaling pathway that underlies IR-induced apoptosis in ATM cells has remained unknown. The purpose of this study was, therefore, to investigate the apoptotic pathway that underlies IR-induced apoptosis in... |
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